Diabetes and the Role of Inositol-Containing Lipids in Insulin Signaling

摘要: Among metabolic diseases, diabetes is considered one of the most prevalent throughout world. Currently, statistics show that over 10% world’s aged population (60 years and older) suffers from diabetes. As a consequence, it consumes considerable proportion world health expenditure. This review considers both past current research into molecular basis insulin resistance found in type II focuses on role inositol-containing phospholipid metabolism. It has been firmly established activation phosphatidylinositol 3-kinase (PI3-K) important for propagation actions insulin. In addition to 3-phosphorylated phosphatidylinositols formed via action PI3-K, glycosyl-phosphatidylinositol/inositol phosphoglycan (GPI/IPG) signaling component also strongly implicated mediating numerous Although all elements within phenotype have not fully defined, proposed defects transmembrane through malfunction metabolism absenteeism generation phospholipid-derived second messengers may be associated with appearance diabetic phenotype. Pharmaceutical approaches using synthetically produced IPG analogues, which themselves mimic insulin’s actions, alone or combination other drugs, lead way toward introducing alternative therapies coming years.