Prevalence, genotype diversity and determinants of anal HPV infection in HIV-uninfected men having sex with men.

摘要: Abstract Background Anal human papillomavirus (HPV) infection is very common in men having sex with (MSM), but the available data on its burden and characteristics mainly concern HIV-infected individuals. Objectives This study aimed to assess prevalence, spectrum of genotypes, determinants anal HPV metropolitan HIV-1 uninfected MSM. Study design A cohort 258 MSM (median age 32 years, IQR 26–39) enrolled at an STI Clinic was screened for using a highly sensitive PCR-based genotyping method. Medical history behavioral were collected. Results Overall, 74.8% HPV-positive, 56.2% participants being infected by high-risk (HR) types. multiple detected 65.3% HPV-positive MSM, up 10 different types same sample. broad infecting observed, 36 found overall HPV16 representing most type (17.8%). The lifetime recent number sexual partners as well receptive significantly associated infection, confirming role behavior risk infection. However, neither younger first intercourse nor inconsistent use condom Conclusions present findings highlight need create more significant awareness about among HIV-uninfected warrant investigation possible intraepithelial lesions, particularly view increasing cancer incidence populations.