Neuronal cell nuclear factor--a nuclear receptor possibly involved in the control of neurogenesis and neuronal differentiation.
作者： Uta-Maria Bauer , Stefan Schneider-hirsch , Sigrid Reinhardt , Thorsten Pauly , Arno Maus
DOI: 10.1111/J.1432-1033.1997.T01-1-00826.X
关键词: Receptor 、 Molecular biology 、 Nuclear receptor co-repressor 1 、 Biology 、 Neurogenesis 、 Germ cell nuclear factor 、 Retinoic acid 、 Neuroepithelial cell 、 Nuclear receptor coactivator 1 、 Nuclear receptor
摘要: We have cloned from a cDNA library of neuronal derivatives retinoic-acid-induced embryonic carcinoma cells nuclear receptor that may be involved in the control late neurogenesis and early differentiation. The which is practically identical sequence with germ cell factor, has been designated factor (NCNF). NCNF exclusively expressed PCC7-Mz1 cells, expression beginning within hours exposure to retinoic acid. In developing mouse brain, marginal zones neuroepithelium are known contain young postmitotic neurons. binds DRO there by silencing transcription. Because does not recognize hormone response elements other receptors tested heterodimerize these, it probably as homodimer. induce differentiation repressing activity genes permit fates than one.
sci-hub.se 参考文章(63)
B. Durand, M. Saunders, C. Gaudon, B. Roy, R. Losson, P. Chambon, Activation function 2 (AF-2) of retinoic acid receptor and 9-cis retinoic acid receptor: presence of a conserved autonomous constitutive activating domain and influence of the nature of the response element on AF-2 activity. The EMBO Journal. ,vol. 13, pp. 5370- 5382 ,(1994) , 10.1002/J.1460-2075.1994.TB06872.X
Guy Riddihough, Hugh R. B. Pelham, An ecdysone response element in the Drosophila hsp27 promoter. The EMBO Journal. ,vol. 6, pp. 3729- 3734 ,(1987) , 10.1002/J.1460-2075.1987.TB02707.X
A.J. Cooney, X. Leng, S.Y. Tsai, B.W. O'Malley, M.J. Tsai, Multiple mechanisms of chicken ovalbumin upstream promoter transcription factor-dependent repression of transactivation by the vitamin D, thyroid hormone, and retinoic acid receptors. Journal of Biological Chemistry. ,vol. 268, pp. 4152- 4160 ,(1993) , 10.1016/S0021-9258(18)53592-4
G Fischer, V Kunemund, M Schachner, Neurite outgrowth patterns in cerebellar microexplant cultures are affected by antibodies to the cell surface glycoprotein L1 The Journal of Neuroscience. ,vol. 6, pp. 605- 612 ,(1986) , 10.1523/JNEUROSCI.06-02-00605.1986
F.G. Rathjen, M. Schachner, Immunocytological and biochemical characterization of a new neuronal cell surface component (L1 antigen) which is involved in cell adhesion. The EMBO Journal. ,vol. 3, pp. 1- 10 ,(1984) , 10.1002/J.1460-2075.1984.TB01753.X
R.M. Harland, D. Frank, M.E. Bolce, A. Hemmati-Brivanlou, B.D. Brown, H.L. Sive, Localization of specific mRNAs in Xenopus embryos by whole-mount in situ hybridization. Development. ,vol. 110, pp. 325- 330 ,(1990) , 10.1242/DEV.110.2.325
C Chen, H Okayama, High-efficiency transformation of mammalian cells by plasmid DNA. Molecular and Cellular Biology. ,vol. 7, pp. 2745- 2752 ,(1987) , 10.1128/MCB.7.8.2745
David M. Heery, Benoit Pierrat, Hinrich Gronemeyer, Pierre Chambon, Régine Losson, Homo- and heterodimers of the retinoid X receptor (RXR) activate transcription in yeast Nucleic Acids Research. ,vol. 22, pp. 726- 731 ,(1994) , 10.1093/NAR/22.5.726
J. Don Chen, Ronald M. Evans, Transcriptional co-repressor that interacts with nuclear hormone receptors Nature. ,vol. 377, pp. 454- 457 ,(1995) , 10.1038/377454A0
J. Lee, S. Hollenberg, L Snider, D. Turner, N Lipnick, H Weintraub, Conversion of Xenopus ectoderm into neurons by NeuroD, a basic helix-loop-helix protein Science. ,vol. 268, pp. 836- 844 ,(1995) , 10.1126/SCIENCE.7754368