The expression level of GCNF affects fate choice during neural differentiation of PCC7 cells
作者： Ingrid Koziollek-Drechsler , Ulrike Sattler , Christina Zechel
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摘要: The nuclear receptor GCNF (NR6A1) is required for embryonic survival and development, regulation of fertility. We used a transgenic approach to investigate its role in neural differentiation. As model we chose the embryonal carcinoma cell line PCC7, which reproducibly differentiates into tissue-like pattern neuronal non-neuronal cells after exposure retinoic acid (RA). differentiation gcnf sense antisense clones consistently indicated that expression level positively correlated with development fate. Moreover, failed down-regulate key regulator Oct4 during initial stages This data proposes might promote fate by mechanisms involve repression Oct4.
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