Avaliação da toxicidade reprodutiva da sinvastatina em Ratos machos adultos
作者： Thais Petrochelli Banzato
DOI:
关键词: Cholesterol 、 Biology 、 Epididymis 、 Sperm 、 Sperm motility 、 Uterus 、 Andrology 、 Spermatogenesis 、 Hormone 、 Simvastatin
摘要: Introduction. Statins are lipid lowering agents extensively used in human clinical medical. They exert their effects through inhibition of HMG-CoA reductase, a crucial enzyme cholesterol synthesis. Since is the precursor steroid hormones, drugs that decrease may damage male reproductive function. Aim. Investigate exposure to different doses simvastatin on parameters adult Wistar rats. Methods. Thirty rats were randomly assigned into three groups: (20 or 40 mg/kg), control (vehicle DMSO/oil), and treated for 30 days orally evaluation after euthanasia. Main Outcome Measure. Weight organs; sperm counts, motility morphology; histopathology; hormonal levels fertility. Results. The weight organs, histopathology analysis similar among groups. There was production epididymis number, uterus with fetuses, implant live fetuses numbers animals exposed showed an increase pre-implantation loss abnormal morphology. Conclusion. observed could be associated toxic spermatogenesis, causing potential
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