Considering statins for cholesterol-reduction in children if lifestyle and diet changes do not improve their health: a review of the risks and benefits.

摘要: Children who appear healthy, even if they have one or more recognized cardiovascular risk factors, do not generally outcomes of other vascular disease during childhood. Historically, pediatric medicine has aggressively screened for treated factors in otherwise healthy children. However, studies such as the P-Day Study (Pathobiological Determinants Atherosclerosis Youth), and Bogalusa Heart Study, indicate that children at remarkably young ages can evidence significant atherosclerosis. With increasing prevalence obesity, we expect health problems related to consequences dyslipidemia, hypertriglyceridemia, atherosclerosis future? For many years, medications been available used adult populations treat dyslipidemia. In recent reports short-term safety some these published. none detailed long-term follow-up, therefore described potential late side-effects early cholesterol-lowering therapy, benefits terms reduction delay end-points. 2007, American Association published a scientific statement on use therapy patients. this review paper, discuss current literature children, including statins are currently cautions with using medications. A central tenet is substitute dietary lifestyle interventions, medications, physicians should take every opportunity encourage their parents make diet choices.