Microbiological production of omeprazole metabolites by Cunninghamella elegans
作者： Clive M. Pearce , Marina V. Lushnikova
DOI: 10.1016/J.MOLCATB.2006.04.005
关键词: Metabolite 、 Cunninghamella elegans 、 Phycomycetes 、 Pharmacology 、 Cunninghamella 、 High-performance liquid chromatography 、 Omeprazole 、 Chemistry 、 Biochemistry 、 Incubation 、 Anti ulcer drug
摘要: Incubation of Cunninghamella elegans ATCC 9245 and the anti ulcer drug omeprazole allowed putative fungal metabolites to be isolated in sufficient quantities for structural elucidation. Three produced by fungi were using semi-preparative HPLC their structures identified a combination LC/MS(n) NMR experiments. These isolates will used as reference standards confirmatory analysis mammalian this drug.
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