Analysis of omeprazole, midazolam and hydroxy-metabolites in plasma using liquid chromatography coupled to tandem mass spectrometry
作者： V FRERICHS , C ZARANEK , C HAAS
DOI: 10.1016/J.JCHROMB.2005.07.001
关键词:
摘要: Abstract A method has been developed and validated for the quantitation of midazolam, alphahydroxy-midazolam, omeprazole, hydroxyomeprazole from one 250 μL sample human plasma using high performance liquid chromatography coupled to tandem mass spectrometry. The was a daily working range 0.400–100 ng/mL, with limits detection between 2 15 pg/mL. inter-assay variation less than 15% all analytes at four control concentrations samples were stable three freeze–thaw cycles under analysis conditions 24 h in post-preparative matrix. This used analyze support clinical studies probing activity cytochrome P-450 enzyme system.
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