Rationale for Treatment of Patients With Chronic Heart Failure With Adrenergic Blockade

摘要: Objective. —Chronic heart failure is the leading cause of hospital admissions in patients older than 65 years. Heart due to systolic dysfunction accompanied by activation sympathetic nervous system that contributes progressive symptoms and an increased risk death. While several clinical trials have suggested antagonizing this with β-blocking agents may provide benefit, no clear consensus exists regarding use β-blockers for congestive failure. Therefore, we review pathophysiology as a basis examining these order understand rationale β-blockade treatment Data Source. —English-language journal articles reviews from MEDLINE search abstracts published at major cardiology meetings related either or therapy chronic β-blockers. Study Selection. —Uncontrolled describing initial subsequent randomized, placebo-controlled were included. Conclusions. —Sympathetic contributor severity disease well its progression over time. Antagonism effects, via β-blocker therapy, appears overall improve both quality life survival. However, place cornerstone depends on results large-scale, trials. (JAMA. 1995;274:1462-1467)