CaV1.2 sparklets in heart and vascular smooth muscle
作者： Manuel F. Navedo , Luis F. Santana
DOI: 10.1016/J.YJMCC.2012.11.018
关键词: Biochemistry 、 Cell biology 、 Vascular smooth muscle 、 Sarcolemma 、 Calcium signaling 、 T-type calcium channel 、 Biology 、 Voltage-dependent calcium channel 、 Protein kinase C 、 Cardiac action potential 、 Protein kinase A
摘要: CaV1.2 sparklets are local elevations in intracellular Ca(2+) ([Ca(2+)]i) resulting from the opening of a single or small cluster voltage-gated, dihydropyridine-sensitive channels. Activation is an early event signaling cascade that couples membrane depolarization to contraction (i.e., excitation-contraction coupling) cardiac and arterial smooth muscle. Here, we review recent work on molecular biophysical mechanisms regulate sparklet activity these cells. tightly regulated by cohort protein kinases phosphatases targeted specific regions sarcolemma anchoring AKAP150. We discuss model for control influx via channels which complex formed AKAP79/150, kinase C, A, calcineurin regulates individual also facilitates coordinated activation clusters This results amplification influx, strengthens coupling vascular
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sci-hub.se 参考文章(57)
Shi-Qiang Wang, Long-Sheng Song, Edward G. Lakatta, Heping Cheng, Ca2+ signalling between single L-type Ca2+ channels and ryanodine receptors in heart cells. Nature. ,vol. 410, pp. 592- 596 ,(2001) , 10.1038/35069083
Luis F. Santana, Manuel F. Navedo, Natural inequalities: why some L-type Ca2+ channels work harder than others The Journal of General Physiology. ,vol. 136, pp. 143- 147 ,(2010) , 10.1085/JGP.200910391
Amanda L. Vega, Can Yuan, V. Scott Votaw, Luis F. Santana, Dynamic Changes in Sarcoplasmic Reticulum Structure in Ventricular Myocytes BioMed Research International. ,vol. 2011, pp. 382586- 382586 ,(2011) , 10.1155/2011/382586
Mitsuru Horiba, Takao Muto, Norihiro Ueda, Tobias Opthof, Keiko Miwa, Mayumi Hojo, Jong-Kook Lee, Kaichiro Kamiya, Itsuo Kodama, Kenji Yasui, T-type Ca2+ channel blockers prevent cardiac cell hypertrophy through an inhibition of calcineurin-NFAT3 activation as well as L-type Ca2+ channel blockers Life Sciences. ,vol. 82, pp. 554- 560 ,(2008) , 10.1016/J.LFS.2007.11.010
Michelle A. Digman, Claire M. Brown, Parijat Sengupta, Paul W. Wiseman, Alan R. Horwitz, Enrico Gratton, Measuring fast dynamics in solutions and cells with a laser scanning microscope. Biophysical Journal. ,vol. 89, pp. 1317- 1327 ,(2005) , 10.1529/BIOPHYSJ.105.062836
Edwin D. Moore, Tilman Voigt, Yvonne M. Kobayashi, Gerrit Isenberg, Fred S. Fay, Maria F. Gallitelli, Clara Franzini-Armstrong, Organization of Ca2+ release units in excitable smooth muscle of the guinea-pig urinary bladder. Biophysical Journal. ,vol. 87, pp. 1836- 1847 ,(2004) , 10.1529/BIOPHYSJ.104.044123
Gregory C. Amberg, Charles F. Rossow, Manuel F. Navedo, Luis F. Santana, NFATc3 Regulates Kv2.1 Expression in Arterial Smooth Muscle Journal of Biological Chemistry. ,vol. 279, pp. 47326- 47334 ,(2004) , 10.1074/JBC.M408789200
John P. Bannister, Adebowale Adebiyi, Guiling Zhao, Damodaran Narayanan, Candice M. Thomas, Jessie Y. Feng, Jonathan H. Jaggar, Smooth Muscle Cell α2δ-1 Subunits Are Essential for Vasoregulation by CaV1.2 Channels Circulation Research. ,vol. 105, pp. 948- 955 ,(2009) , 10.1161/CIRCRESAHA.109.203620
L. Hymel, J. Striessnig, H. Glossmann, H. Schindler, Purified skeletal muscle 1,4-dihydropyridine receptor forms phosphorylation-dependent oligomeric calcium channels in planar bilayers. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 85, pp. 4290- 4294 ,(1988) , 10.1073/PNAS.85.12.4290
Seth F. Oliveria, Mark L. Dell'Acqua, William A. Sather, AKAP79/150 Anchoring of Calcineurin Controls Neuronal L-Type Ca2+ Channel Activity and Nuclear Signaling Neuron. ,vol. 55, pp. 261- 275 ,(2007) , 10.1016/J.NEURON.2007.06.032