Hamlet's augury: how to manage discontinuation of mood stabilizers in bipolar disorder.

摘要: Research has generated good quality evidence about the treatment and management of bipolar disorder in acute and, to some degree, sub-acute/continuation phases. This informed various guidelines (BD). However, for long-term or maintenance phase illness, most peter out absence sufficiently high-quality research evidence, remain vague. is particularly evident important clinical question discontinuing mood stabilizing pharmacological agents after a period remission been achieved. The aim this review put together current existing stabilizers order come up with structured coherent strategy managing such discontinuation make recommendations future research. To end, we reviewed main relevant subsequent following publication these guidelines. recommended BD usually considered within same principles applicable any chronic health condition (e.g. hypertension diabetes) where focus on continuing at minimum effective medication dose often life-long, switching alternative choice due side-effects very few, if any, indications complete cessation. strong high rate non-concordance BD, aspect that should be given consideration every treatment.