Toxicity of aminoglycoside antibiotics.

摘要: In cats, aminoclycosides cause vestibular damage followed in a few days by renal damage. The reverse is true the dog, except that streptomycin causes prior to To avoid toxicities, therapeutic doses of aminoglycosides should not be given longer than week and they cautiously animals with impairment. Failure kidneys eliminate will result very high blood levels, even doses, can further oral administration seldom dangerous when normal are employed. Although it remote, possibility exists impairment intestinal obstruction may become intoxicated. Kanamycin less nephrotoxic dogs neomycin destructive auditory nerve streptomycin. Gentamicin cats twice as toxic apparatus more cochlea or dihydrostreptomycin. Neomycin kanamycin, gentamicin, both dogs. Amikacin similar other aminoglycosides. It also