The Evolution of Gene Regulatory Mechanisms in Bacteria

摘要: Modern bacteria regulate the expression of their genes through a spectrum mechanisms ranging from very simple to those that are highly complex. The regulatory have evolved in concert with means detect changes physical or chemical environment, equipping organism respond change. Regulation can be imposed at each stage gene expression, and networking coordinated control makes for multidimensional relationships vary time space. Understanding how this complexity is not trivial matter, but it attempted. In one popular view, an ‘RNA world’ may preceded modern its DNA-based genomes. Looking evidence RNA-based regulation has been fruitful shows level still much use: conversion genetic information held RNA into protein by translation involves processes open several levels. genomes, transcription fundamental process, over evolutionary bacterial cells invested heavily it. Mechanisms influence activity polymerase legion fall two categories: impede assist process reading information. It seems simply turning on off rarely sufficient: was necessary evolve tuning needs cell promote survival, regardless size sophistication organism’s genome. These ways make operations ‘noisy’, noise useful generating physiological variety among genetically identical cells. becoming clear forces shape nucleoid also guide development elements. For reason evolution will considered context genome architecture.