Ancient RNA Stems That Terminate Transcription

摘要: Multi-subunit RNA polymerases are the enzymes that perform transcription in all living organisms and have emerged before divergence of domains life. The structures catalytic cores their functions during elongation step cycle very similar for multi-subunit polymerases. In contrast, mechanisms terminating synthesis seemingly diverged modern However, recent finding that, much like bacterial transcription, secondary structure is involved termination by eukaryotic polymerase III (pol III), suggests RNA-dependent may archaeal/eukaryotic case pol III, not dedicated hairpins, but formed bodies highly structured transcripts, which clearly remnants from RNA–protein world. Here I discuss similarities differences III.