Understand the acquired resistance of RTK inhibitors by computational receptor tyrosine kinases network.

摘要: Abstract Receptor Tyrosine Kinase inhibitors are the most popular anti-cancer drug types. But resistance is major challenge. Our study on network with 1334 proteins and their 2623 interactions which retrieved from 52 RTKs indicated that were key controllers of protein-protein network. Direct or indirect (shortest path 2) often associated to in literature. The results based KEGG pathway analysis demonstrated Rap1 signal would also contribute inhibitor as well known Ras PI3K/Akt pathway. pathways can crosstalk within between complex signals transduction networks, then activate upstream downstream pathway, and/or other oncogenes, lead acquired resistance. gave a systematically global view understand provided clue how combine different targets for synergy targeted inhibitors.