Insulin-like growth factor 1 pathway mutations and protein expression in resected non-small cell lung cancer.

摘要: Summary The purpose of this study was to characterize the prevalence insulin-like growth factor 1 receptor ( IGF1R ) mutations, single nucleotide polymorphisms (SNP), and protein overexpression in surgically resected non–small cell lung cancers relation patient characteristics prognosis. This retrospective conducted on 304 patients with who underwent curative pulmonary resection (median follow-up for surviving patients, 3.6 years). gene alterations (n = 304) expression 181) were evaluated by polymerase chain reaction–based assays immunohistochemistry, respectively. Membranous cytoplasmic staining analyzed separately. In an exploratory analysis, silent mutation exon 16 3 mutations introns comprising tyrosine kinase domain detected. Moreover, evaluating selected SNPs, adenocarcinomas homozygous rs8038415 T-allele had a significantly better survival P .025) but no different disease-free survival. Regarding expression, membranous not higher squamous carcinomas versus other histologies .08). No association between SNP variations found. is does correlate SNPs can be detected may harbor prognostic value. These interest when as potential therapeutic target should receive further research.