Insulin-like growth factor-1 receptor as a novel prognostic marker and its implication as a cotarget in the treatment of human adenocarcinoma of the esophagus.

摘要: Insulin-like growth factor-1 receptor (IGF-1R) and human epidermal factor receptor-2 (HER2) expression has been found to be a key regulator of tumorigenesis. The purpose our study was establish the prognostic significance IGF-1R in esophageal cancer determine effect HER2 targeting with α-IR3 Herceptin™ antibodies on proliferation cells vitro. clinicopathological correlations were analyzed tissue microarray containing 234 specimens (133 adenocarcinomas 101 squamous cell carcinomas). Proliferation changes associated blockage evaluated unique lines Pt1590 LN1590. levels, activation phosphorylation status downstream signaling proteins involved pathways by Western blotting. overexpression detected 121 (52%) tumors examined. In subgroup 87 HER2-positive tumors, 93.1% showed concordant for IGF-1R. identified as variable reduced overall survival adenocarcinoma (p = 0.05), but not carcinoma. combination more effective inhibiting vitro than treatment either agent alone < 0.01). This decrease protein levels suppression Akt- MAP kinase phosphorylation. can used novel marker esophagus. Cotreatment might become valuable option adenocarcinoma.