Trastuzumab has anti-metastatic and anti-angiogenic activity in a spontaneous metastasis xenograft model of esophageal adenocarcinoma
作者： Tobias Lange , Michael F. Nentwich , Manuel Lüth , Emre Yekebas , Udo Schumacher
DOI: 10.1016/J.CANLET.2011.04.013
关键词: Spontaneous metastasis 、 Trastuzumab 、 Lung 、 Esophageal adenocarcinoma 、 In vivo 、 Cell culture 、 Oncology 、 Angiogenesis 、 In vitro 、 Internal medicine 、 Medicine
摘要: Abstract HER-2/neu over-expression occurs in 10–40% of patients with esophageal adenocarcinoma. Therefore, inhibitory effects trastuzumab on proliferation, neoangiogenesis and metastatic spread the adenocarcinoma cell line PT1590 were investigated (subcutaneous xenograft model). revealed an amplified copy number c - erbB2 occured tumors spontaneous lung metastases. proliferation was significantly inhibited by vitro . In vivo, tumor weight, volume, microvessel density metastases decreased after three weeks treatment. These data suggest importance for encourages clinical trials.
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sci-hub.se 参考文章(37)
Carlos L. Arteaga, Hirokazu Kurokawa, ErbB (HER) Receptors Can Abrogate Antiestrogen Action in Human Breast Cancer by Multiple Signaling Mechanisms Clinical Cancer Research. ,vol. 9, ,(2003)
Joan Albanell, Larry Norton, Jose Baselga, Young Mee Kim, John Mendelsohn, Recombinant Humanized anti-HER2 Antibody (Herceptin) Enhances the Antitumor Activity of Paclitaxel and Doxorubicin Against HER2/neu Overexpressing Human Breast Cancer Xenografts Cancer Research. ,vol. 58, pp. 2825- 2831 ,(1998)
A. Jemal, R. Siegel, E. Ward, T. Murray, J. Xu, C. Smigal, M. J. Thun, Cancer statistics, 2006. CA: A Cancer Journal for Clinicians. ,vol. 56, pp. 106- 130 ,(2006) , 10.3322/CANJCLIN.56.2.106
Thomas P. Brien, Robert D. Odze, Christine E. Sheehan, Barbara J. McKenna, Jeffrey S. Ross, HER-2/neu gene amplification by FISH predicts poor survival in Barrett's esophagus-associated adenocarcinoma Human Pathology. ,vol. 31, pp. 35- 39 ,(2000) , 10.1016/S0046-8177(00)80195-1
Rhoda M. Alani, Courtney F. Silverthorn, Kate Orosz, Tumor angiogenesis in mice and men. Cancer Biology & Therapy. ,vol. 3, pp. 498- 500 ,(2004) , 10.4161/CBT.3.6.930
Tatyana Kalinina, Maximilian Bockhorn, Jussuf T. Kaifi, Sabrina Thieltges, Cenap Güngör, Katharina E. Effenberger, Andrea Strelow, Uta Reichelt, Guido Sauter, Klaus Pantel, Jakob R. Izbicki, Emre F. Yekebas, Insulin-like growth factor-1 receptor as a novel prognostic marker and its implication as a cotarget in the treatment of human adenocarcinoma of the esophagus. International Journal of Cancer. ,vol. 127, pp. 1931- 1940 ,(2010) , 10.1002/IJC.25196
James D. Mueller, Hubert J. Stein, Tao Oyang, Shoji Natsugoe, Marcus Feith, Martin Werner, J. Rüdiger Siewert, Frequency and clinical impact of lymph node micrometastasis and tumor cell microinvolvement in patients with adenocarcinoma of the esophagogastric junction. Cancer. ,vol. 89, pp. 1874- 1882 ,(2000) , 10.1002/1097-0142(20001101)89:9<1874::AID-CNCR2>3.3.CO;2-D
Georgia Vogl, Heidi Bartel, Otto Dietze, Cornelia Hauser-Kronberger, HER2 is unlikely to be involved in directly regulating angiogenesis in human breast cancer. Applied Immunohistochemistry & Molecular Morphology. ,vol. 14, pp. 138- 145 ,(2006) , 10.1097/01.PAI.0000168591.58721.A6
M. Dreilich, A. Wanders, D. Brattström, S. Bergström, P. Hesselius, G. Wagenius, M. Bergqvist, HER-2 overexpression (3+) in patients with squamous cell esophageal carcinoma correlates with poorer survival. Diseases of The Esophagus. ,vol. 19, pp. 224- 231 ,(2006) , 10.1111/J.1442-2050.2006.00570.X
Uta Reichelt, Peer Duesedau, Maria Ch Tsourlakis, Alexander Quaas, Björn C Link, Paulus G Schurr, Jussuf T Kaifi, Stephanie J Gros, Emre F Yekebas, Andreas Marx, Ronald Simon, Jakob R Izbicki, Guido Sauter, Frequent homogeneous HER-2 amplification in primary and metastatic adenocarcinoma of the esophagus. Modern Pathology. ,vol. 20, pp. 120- 129 ,(2007) , 10.1038/MODPATHOL.3800712