Insulin-like growth factors and cancer.
作者： Gregor Fürstenberger , Hans-Jörg Senn
DOI: 10.1016/S1470-2045(02)00731-3
关键词: Receptor 、 Internal medicine 、 Carcinogenesis 、 Cancer research 、 Cell growth 、 Mediator 、 IGFBP3 、 Inhibitor of apoptosis 、 Cancer 、 Biology 、 Insulin-like growth factor 1 receptor 、 Endocrinology
摘要: Summary Interest in insulin-like growth factors (IGFs) and their effect on carcinogenesis has increased recently because high serum concentrations of IGF1 are associated with an risk breast, prostate, colorectal, lung cancers. Physiologically, is the major mediator effects hormone; it thus a strong influence cell proliferation differentiation potent inhibitor apoptosis. The action predominantly mediated through receptor (IGF1R). IGF1R involved several oncogenic transformation processes. availability unbound for interaction modulated by IGF-binding proteins (IGFBP1–6). IGFBPs, especially IGFBP3, have independent growth, example, IGFBP3 proapoptotic activities both dependent p53.
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