Activation of insulin-like growth factor 1 receptor in patients with non-small cell lung cancer

摘要: // Jin-Soo Kim 1,5 , Edward S. 1 Diane Liu 2 J. Jack Lee Carmen Behrens 3 Scott M. Lippman Waun Ki Hong Ignacio I. Wistuba 1,3 Euni 4 and Ho-Young Department of Thoracic/Head & Neck Medical Oncology, The University Texas MD Anderson Cancer Center, Houston, TX, USA Biostatistics, Pathology, College Pharmacy Research Institute Pharmaceutical Sciences, Seoul National University, Seoul, Republic Korea 5 Present address: Internal Medicine, Boramae Correspondence to: Lee, email: Keywords : non-small cell lung cancer, insulin-like growth factor-1 receptor, prognosis, tissue microarray Received February 23, 2015 Accepted March 20, Published April 12, Abstract According to previous reports demonstrating the implication factor receptor (IGF-1R) signaling in cancer (NSCLC), this study, potential prognostic values IGF-1R expression/activation were analyzed. expression activation evaluated two (TMA) sets from NSCLC patients ( N  = 352 for TMA I,  = 353 II). Alterations protein or mRNA using publicly available data Genome Atlas (TCGA). We found that membranous cytoplasmic expressions significantly associated with squamous carcinoma (SCC) both TMAs. Analysis TCGA revealed increased levels patients, which was reductions overall survival (OS) (median 26.51 vs. 47.77 months, P  = 0.017) disease-free 17.44 37.65  = 0.045) only adenocarcinoma (ADC). These suggest is activated NSCLC, particularly those SCC. a especially ADC. Further studies are warranted investigate value patients.