Lung cancer chemoprevention: current status and future prospects
作者： Robert L. Keith , York E. Miller
DOI: 10.1038/NRCLINONC.2013.64
关键词: Adenocarcinoma 、 Medicine 、 Internal medicine 、 Oncology 、 Disease 、 Observational study 、 Lung cancer 、 Lung tumours 、 Clinical trial 、 Carcinogenesis 、 Pharmacology 、 Smoking cessation
摘要: Lung cancer is the leading cause of death worldwide, making it an attractive disease for chemoprevention. Although avoidance tobacco use and smoking cessation will have greatest impact on lung development, chemoprevention could prove to be very effective, particularly in former smokers. Chemoprevention agents reverse or inhibit carcinogenesis has been successfully applied other common malignancies. Despite prior studies failing identify effective agents, we now ability high-risk populations, our understanding tumour premalignant biology continues advance. There are distinct histological lesions that can reproducibly graded as precursors non-small-cell similar precursor exist adenocarcinoma. These being targeted by chemopreventive current trials continue studied future. In addition, biomarkers predict risk response investigated validated. this Review, discuss principles chemoprevention, data from preclinical models, completed clinical observational studies, describe new treatments novel pathways future efforts.
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