Effect of nitric oxide synthase on multiple drug resistance is related to Wnt signaling in non-small cell lung cancer.
作者： YANG LI , CHENGYUAN MA , XU SHI , ZHONGMEI WEN , DAN LI
DOI: 10.3892/OR.2014.3351
关键词:
摘要: Multiple drug resistance (MDR) is considered a major challenge in the clinical treatment of non-small cell lung cancer (NSCLC). Both nitric oxide synthase (iNOS) and Wnt signaling pathway participate regulation resistance, but interaction between them remains unclear. In present study, we detected activation Wnt/β- catenin iNOS-induced drug-resistant cells, compared effect canonical noncanonical on level iNOS. Moreover, investi- gated expression Wnt/β-catenin downstream factors its main inhibitors. The results indicated iNOS- induced was possibly mediated by glutathione S-transferase-π (GST-π) topoisomerase IIα (TOPO IIα), not P-glycoprotein (P-gp), this process closely associated with signaling, less pathways. mecha- nism iNOS promoting mainly dependent inverse Dickkopf-1 (DKK-1) secreted frizzled-related protein-1 (SFRP-1). Clarifying relationship may provide insight into better understanding mechanism development NSCLC.
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