作者: Arunangshu Das , James D. Bortner , Cesar Aliaga , Timothy Cooper , Anne Stanley
DOI: 10.1016/J.EUPROT.2015.07.015
关键词: Cancer research 、 Adenocarcinoma 、 Proteomics 、 Lung cancer 、 Adenoma 、 Annexin A5 、 Atypia 、 Carcinogenesis 、 Bioinformatics 、 Hyperplasia 、 Chemistry
摘要: Abstract We used a proteomics approach (iTRAQ) to identify differentially expressed lung proteins during early stages of the tobacco carcinogen, NNK-induced tumorigenesis (hyperplasia/atypia, 4–10 weeks and adenoma, 25 week) prior detection adenocarcinoma in A/J mice. identified 790 at week 4 710 10 with >95% confidence Local False Discovery Rate estimation less than 5%. have demonstrated that NNK altered multiple protein (e.g., Carbonyl Reductase, Annexin A5/6, Selenbp1, Hmgb1 Hsp90b1) expressions lesions which can be as potential biomarkers for cancer.