Proteomic profiling of hyperplasia/atypia and adenoma-induced by NNK in mouse lung identified multiple proteins as potential biomarkers for early detection

作者: Arunangshu Das , James D. Bortner , Cesar Aliaga , Timothy Cooper , Anne Stanley

DOI: 10.1016/J.EUPROT.2015.07.015

关键词: Cancer researchAdenocarcinomaProteomicsLung cancerAdenomaAnnexin A5AtypiaCarcinogenesisBioinformaticsHyperplasiaChemistry

摘要: Abstract We used a proteomics approach (iTRAQ) to identify differentially expressed lung proteins during early stages of the tobacco carcinogen, NNK-induced tumorigenesis (hyperplasia/atypia, 4–10 weeks and adenoma, 25 week) prior detection adenocarcinoma in A/J mice. identified 790 at week 4 710 10 with >95% confidence Local False Discovery Rate estimation less than 5%. have demonstrated that NNK altered multiple protein (e.g., Carbonyl Reductase, Annexin A5/6, Selenbp1, Hmgb1 Hsp90b1) expressions lesions which can be as potential biomarkers for cancer.

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