Polimorfismos en la región promotora del gen del TNFa en artritis reumatoidea
作者： Reynaldo Badillo , Javier Martín , Olga María Moreno , Clara Isabel González , Diego Luis Saaibi
DOI:
关键词: Single-nucleotide polymorphism 、 Allele frequency 、 Medicine 、 Rheumatoid factor 、 Population 、 Molecular biology
摘要: RESUMEN El objetivo de este estudio fue determinar la frecuencia y potencial relevancia los polimorfismos del gen TNFA -308 -238 en susceptibilidad severidad artritis reumatoidea (AR). Se determinaron las frecuencias genotipicas alelicas nucleotido simple (SNPs) 102 casos con AR controles sanos. No se encontraron diferencias estadisticamente significativas entre o analizados cuando compararon pacientes el grupo control. La genotipo GA, mostro una tendencia a asociacion inicio tardio patologia, ³45 anos (p=0,046) ausencia cirugia. polimorfismo -308A tendencia, no significativa estadisticamente, niveles altos factor reumatoideo (FR) (p=0,06). Las difieren reportadas poblacion antioquena son comparables algunas poblaciones caucasicas. Los resultados sugieren que nuestra estos estan mas relacionados al desarrollo AR. Palabras Clave: Artritis (AR), polimorfismos, necrosis tumoral (TNF), interleuquina, reumatoideo, susceptibilidad. ABSTRACT The aim of this study was to determine the frequency and potential relevance gene polymorphisms in susceptibility severity rheumatoid arthritis (RA). genotype allelic frequencies nucleotide were determined cases with RA healthy controls. There not statistically significant differences between allele analyzed when patients where compared control group. -238AG, showed tendency late beginning pathology, years (p=0.046) without surgery. tendency, high levels (RF) (p=0.06). alellic differ those reported "antioquena" population they are comparable some Caucasian populations. results suggest that our these more related development RA. Key Words: Rheumatoid Arthritis (RA), polymorphisms, tumor interleukine, factor, susceptibility.
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