Variants of tumor necrosis factor-induced protein 3 gene are associated with left ventricular hypertrophy in hypertensive patients.

摘要: BACKGROUND Tumor necrosis factor-induced protein 3 (TNFAIP3) gene has been shown important in cardiac remodeling. The aim of the present study was to investigate whether variants TNFAIP3 are associated with left ventricular hypertrophy (LVH) hypertensive patients. METHODS Four representatives all other single nucleotide polymorphisms (SNPs) were tested for association two independent populations (n = 2120 and n 324). RESULTS We found that only tag SNP (rs5029939) consistently lower hypertensives than those without populations, indicating a protective effect on LVH (odds ratio (OR) (95% confidence interval (CI)) 0.58 (0.358 - 0.863), P 0.035; OR (95%CI) 0.477 (0.225 0.815), < 0.05, respectively). Multiple regression analyses confirmed patients G allele rs5029939 had less thickness inter-ventricular septum, posterior wall, relative wall mass index did CC both (all 0.01). CONCLUSION These findings indicate may serve as novel genetic marker development hypertension.