Identification of anesthetic-induced expression changes using DNA microarray
作者： ZAIQI YANG , MENGYUAN ZHANG , GONGMING WANG , PIHONG WEI , SHENQIANG GAO
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摘要: The present study aimed to identify changes in atrial gene expression induced by sevoflurane and propofol using DNA microarray. profiles of GSE4386 samples, obtained from patients who had received either the anesthetic gas or intravenous prior following off-pump coronary artery bypass graft (CABG) surgery, were downloaded Gene Expression Omnibus database. differentially expressed genes (DEGs) groups then identified compared. Subsequently, a functional enrichment analysis was performed for DEGs. interactive modules common, sevoflurane-specific propofol-specific DEGs constructed biological processes. percentages common 31.3 (275/879) 94.8% (275/290) group groups, respectively. categories similar. Overall, two, one, one DEGs, specific involved cellular processes, including 'regulation transcription' process', which similar annotations Therefore, may synergistically reduce myocardial reperfusion injury undergoing CABG surgery.
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