Reactive Oxygen Species Responsive Nanoprodrug to Treat Intracranial Glioblastoma
作者： Bong-Seop Lee , Takayuki Amano , Hong Qiang Wang , Joe L. Pantoja , Chi Woo Yoon
DOI: 10.1021/NN400347J
关键词: Pharmacology 、 Camptothecin 、 Endocytosis 、 Chemistry 、 Drug delivery 、 In vivo 、 Glioma 、 Tumor microenvironment 、 Prodrug 、 Blood–brain barrier
摘要: Chemotherapy for intracranial gliomas is hampered by limited delivery of therapeutic agents through the blood brain barrier (BBB). An optimal agent tumors would selectively cross BBB, accumulates in tumor tissue and be activated from an innocuous prodrug within tumor. Here we show tumor-targeted efficacy a nanometer-sized (nanoprodrug) camptothecin (CPT) to treat experimental glioblastoma multiforme (GBM). The CPT nanoprodrug was prepared using spontaneous nanoemulsification biodegradable, antioxidant α-tocopherol. oxidized more efficiently than nonoxidized nanoprodrug, suggesting enhanced oxidative microenvironment. vitro imaging U-87 MG glioma cells revealed efficient intracellular uptake via direct cell membrane penetration rather endocytosis. vivo study mice demonstrated that nanopr...
acs.org
core.ac.uk
sci-hub.se 参考文章(76)
D. Krex, B. Klink, C. Hartmann, A. von Deimling, T. Pietsch, M. Simon, M. Sabel, J. P. Steinbach, O. Heese, G. Reifenberger, M. Weller, G. Schackert, , Long-term survival with glioblastoma multiforme Brain. ,vol. 130, pp. 2596- 2606 ,(2007) , 10.1093/BRAIN/AWM204
Markus Bredel, Josef Zentner, Brain-tumour drug resistance: the bare essentials Lancet Oncology. ,vol. 3, pp. 397- 406 ,(2002) , 10.1016/S1470-2045(02)00786-6
Lucienne Juillerat-Jeanneret, The targeted delivery of cancer drugs across the blood-brain barrier: chemical modifications of drugs or drug-nanoparticles? Drug Discovery Today. ,vol. 13, pp. 1099- 1106 ,(2008) , 10.1016/J.DRUDIS.2008.09.005
Usha S. Vasthare, Ronald F. Tuma, Fan Yuan, Yves Boucher, Rakesh K. Jain, Hassan A. Salehi, Vascular permeability and microcirculation of gliomas and mammary carcinomas transplanted in rat and mouse cranial windows Cancer Research. ,vol. 54, pp. 4564- 4568 ,(1994)
Yossi Gilgun-Sherki, Eldad Melamed, Daniel Offen, Oxidative stress induced-neurodegenerative diseases: the need for antioxidants that penetrate the blood brain barrier. Neuropharmacology. ,vol. 40, pp. 959- 975 ,(2001) , 10.1016/S0028-3908(01)00019-3
Dai Fukumura, Vladimir P. Torchilin, Fan Yuan, Rakesh K. Jain, David A. Berk, Marc Dellian, Michael Leunig, Vascular Permeability in a Human Tumor Xenograft: Molecular Size Dependence and Cutoff Size Cancer Research. ,vol. 55, pp. 3752- 3756 ,(1995)
J. Carrell Morris, The Acid Ionization Constant of HOCl from 5 to 35 The Journal of Physical Chemistry. ,vol. 70, pp. 3798- 3805 ,(1966) , 10.1021/J100884A007
Y H Hsiang, R Hertzberg, S Hecht, L F Liu, Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I. Journal of Biological Chemistry. ,vol. 260, pp. 14873- 14878 ,(1985) , 10.1016/S0021-9258(17)38654-4
Navdeep S. Chandel, David S. McClintock, Carlos E. Feliciano, Teresa M. Wood, J. Andres Melendez, Ana M. Rodriguez, Paul T. Schumacker, Reactive Oxygen Species Generated at Mitochondrial Complex III Stabilize Hypoxia-inducible Factor-1α during Hypoxia Journal of Biological Chemistry. ,vol. 275, pp. 25130- 25138 ,(2000) , 10.1074/JBC.M001914200
Jayanth Panyam, Vinod Labhasetwar, Dynamics of endocytosis and exocytosis of poly(D,L-lactide-co-glycolide) nanoparticles in vascular smooth muscle cells. Pharmaceutical Research. ,vol. 20, pp. 212- 220 ,(2003) , 10.1023/A:1022219003551