Sex differences in neurotensin and substance P following nicotine self-administration in rats.
作者： Steven T. Pittenger , Natashia Swalve , Shinnyi Chou , Misty D. Smith , Amanda J. Hoonakker
DOI: 10.1002/SYN.21907
关键词: Substance P 、 Nicotine 、 Nucleus accumbens 、 Neurotensin 、 Dopamine 、 Globus pallidus 、 Medicine 、 Endocrinology 、 Neuropeptide 、 Internal medicine 、 Ventral tegmental area
摘要: Investigator-administered nicotine alters neurotensin and substance P levels in Sprague-Dawley rats. This finding suggested a role of the dopamine-related endogenous neuropeptides addiction. We sought to extend this observation by determining responses systems (assessed using radioimmunoassay) male female rats following self-administration (SA). Male were trained self-administer nicotine, or receive saline infusions yoked nicotine-administering rat during daily sessions (1-h; 21 days). Brains extracted 3 h after last SA session. Nicotine increased tissue males anterior posterior caudate, globus pallidus, frontal cortex, nucleus accumbens core shell, ventral tegmental area. also females but not There fewer sex differences observed systems. both A difference was core, where males, yet decreased females. The regulation may play susceptibility dependence males. Synapse 70:336-346, 2016. © 2016 Wiley Periodicals, Inc.
elsevier.com
sci-hub.se 参考文章(76)
Kenneth A. Perkins, Smoking cessation in women. Special considerations. CNS Drugs. ,vol. 15, pp. 391- 411 ,(2001) , 10.2165/00023210-200115050-00005
Kenneth A. Perkins, Sex differences in nicotine reinforcement and reward: influences on the persistence of tobacco smoking. Nebraska Symposium on Motivation. Nebraska Symposium on Motivation. ,vol. 55, pp. 143- 169 ,(2008) , 10.1007/978-0-387-78748-0_9
Sophia Li, Sheng Zou, Kathleen Coen, Douglas Funk, Megan J Shram, AD Lê, None, Sex differences in yohimbine-induced increases in the reinforcing efficacy of nicotine in adolescent rats. Addiction Biology. ,vol. 19, pp. 156- 164 ,(2014) , 10.1111/J.1369-1600.2012.00473.X
Mario E. Alburges, Amanda J. Hoonakker, Kristen A. Horner, Annette E. Fleckenstein, Glen R. Hanson, Methylphenidate alters basal ganglia neurotensin systems through dopaminergic mechanisms: a comparison with cocaine treatment Journal of Neurochemistry. ,vol. 117, pp. 470- 478 ,(2011) , 10.1111/J.1471-4159.2011.07215.X
Mark J. Alexander, Zsolt J. Kiraly, Susan E. Leeman, Sexually dimorphic distribution of neurotensin/neuromedin N mRNA in the rat preoptic area The Journal of Comparative Neurology. ,vol. 311, pp. 84- 96 ,(1991) , 10.1002/CNE.903110107
Paul Fredrickson, Mona Boules, Sally Yerbury, Elliott Richelson, Novel neurotensin analog blocks the initiation and expression of nicotine-induced locomotor sensitization Brain Research. ,vol. 979, pp. 245- 248 ,(2003) , 10.1016/S0006-8993(03)02895-6
R. Maehler, M. Dadmarz, W.H. Vogel, Determinants of the Voluntary Consumption of Nicotine by Rats Neuropsychobiology. ,vol. 41, pp. 200- 204 ,(2000) , 10.1159/000026660
Carmela M. Reichel, Jessica D. Linkugel, Rick A. Bevins, Bupropion differentially impacts acquisition of methamphetamine self-administration and sucrose-maintained behavior. Pharmacology, Biochemistry and Behavior. ,vol. 89, pp. 463- 472 ,(2008) , 10.1016/J.PBB.2008.02.002
J. GRENHOFF, G. ASTON-JONES, T. H. SVENSSON, Nicotinic effects on the firing pattern of midbrain dopamine neurons Acta Physiologica Scandinavica. ,vol. 128, pp. 351- 358 ,(1986) , 10.1111/J.1748-1716.1986.TB07988.X
Carolina Chavez, Marianne Hollaus, Elizabeth Scarr, Geoff Pavey, Andrea Gogos, Maarten van den Buuse, The effect of estrogen on dopamine and serotonin receptor and transporter levels in the brain: An autoradiography study Brain Research. ,vol. 1321, pp. 51- 59 ,(2010) , 10.1016/J.BRAINRES.2009.12.093