Novel neurotensin analog blocks the initiation and expression of nicotine-induced locomotor sensitization
作者： Paul Fredrickson , Mona Boules , Sally Yerbury , Elliott Richelson
DOI: 10.1016/S0006-8993(03)02895-6
关键词:
摘要: Neurotensin is a tridecapeptide that participates in regulation of dopaminergic pathways implicated nicotine addiction. Previously, we showed one our brain-penetrating neurotensin analogs, NT69L, blocks nicotine-induced locomotor sensitization. The present work demonstrates NT69L both the initiation and expression In addition chronic administration blocked acute effects on norepinephrine serotonin prefrontal cortex.
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