Relapse to Cocaine- and Heroin-Seeking Behavior Mediated by Dopamine D2 Receptors Is Time-Dependent and Associated with Behavioral Sensitization
作者： Taco J De Vries , Anton NM Schoffelmeer , Rob Binnekade , Halfdan Raaso , Louk JMJ Vanderschuren
DOI: 10.1016/S0893-133X(01)00293-7
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摘要: The sensitizing properties of drugs abuse have been proposed to play an important role in the persistence drug seeking behavior. We decided evaluate temporal relationship dopamine D2 receptor-mediated behavior and behavioral sensitization animals with a history cocaine heroin self-administration. During early phases withdrawal ( 3 weeks), reinstatement by quinpirole was still apparent, but less robust. In heroin-trained rats, increases responding were no longer observed. Interestingly, observed cocaine-trained absent rats. Thus, it appears that receptors time-dependent relapse which is strongly associated behaviorally sensitized state.
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