Modeling and Simulation of Lab-on-a-Chip Systems

摘要: Abstract : Behavioral modeling and schematic simulation methodology for top-down Lab-on-a-Chip (LoC) design is presented. The methodology: decomposing a complex LoC system into small set of elements. Each the elements associated with parameterized behavioral model that describes its electric biofluidic behavior. Key issues: representation, multi-physics numerical experimental validation. effort focuses on sample transport in devices. Turn Joule heating induced dispersion electrophoretic separation chips are studied using method moments. skew species band effectively represented by Fourier cosine series coefficients, obtained analytically. These coefficients capture effect performance various chip geometries (including multiple turns). Variations concentration profiles laminar diffusion-based micromixers also derived representation. holds arbitrary flow ratios inlet profiles, accurately considers overall effects device topology, size field mixing performance. In addition, simplified reaction developed integrated models to perform system-level simulations an system. Simulation results at both element levels validated against data. Excellent accuracy (generally less than 100 times) have been achieved when compared finite analysis. adapted pressure driven used propose novel gradient generator design. resulting framework significant contribution balancing needs efficiency thus enabling iterative systems.