Efficacy of the avermectins against filarial parasites: A short review
作者： W. C. Campbell
DOI: 10.1007/BF02214991
关键词: Mastomys 、 Filarial worms 、 Microbiology 、 Host (biology) 、 Immunology 、 Larva 、 Brugia malayi 、 CATS 、 Microfilaria 、 Biology 、 Low dosage
摘要: The avermectins are macrocyclic lactones produced byStreptomyces avermitilis. One of them has been chemically modified and given the non-proprietary name invermectin. compounds have shown efficacy against various stages filarial parasites. With respect to pre-adult in mammalian host, activity observed againstDirofilaria immitis ferrets dogs, andDipetalonema viteae andLitomosoides carinii jirds (Meriones); but not developing ofBrugia spp. orOnchocerca cattle. adult worms, except case ofSetaria equina horses possiblyDipetalonema viteae jirds. first stage larva (microfilaria) dogs,Brugia malayi multimammate rats (Mastomys),Dipetalonema viteae andOnchocerca cattle; microfilariae ofBrugia pahangi or cats. Efficacy parasites following oral parenteral administration drug, sometimes at extremely low dosage. For example, a single dosage 0.05 mg/kg was highly active third fourth larval ofD. immitis dogs.
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