The main factors influencing canine demodicosis treatment outcome and determination of optimal therapy

摘要: The main idea of this research was to evaluate the efficacy canine demodicosis conventional treatments using mathematical analyses. All available papers published between 1980 and 2014 were used in study. One hundred six clinical trials enrolling 3414 cases generalized dogs are studied. Dogs entered analysis only ones which disease occurred naturally, excluding studies transplantation Demodex canis mites done from other animals. In acaricide treatments, sorted according active substances (moxidectin, amitraz, doramectin, ivermectin, milbemycin oxime), way application (spot-on, dips, orally, or subcutaneous), concentration, interval as input parameters modeling. Data interest treatment outcome, number that went into remission, animals not responding microscopically, average duration therapy, follow-up period, patients with recurrence, adverse effects, side effects. lost when discontinued, due various reasons connection therapy protocol, considered. Statistical analyses applied for prediction drugs’ effectiveness. Developed models showed satisfactorily r 2, higher than 0.87. Good evidence recommending use oxime PO (0.5 mg/kg, daily) moxidectin spot-on (Advocate®, Bayer) weekly is found. A bit less effective therapies based on ivermectin daily), (0.35 mg/kg, amitraz dips (0.05 % solution, weekly), respectively. It important keep mind Advocate® recommended by manufacturer milder cases.