Indirect evidence for nitric oxide involvement in multiple sclerosis by characterization of circulating antibodies directed against conjugated S-nitrosocysteine
作者： Anne I. Boullerne , Klaus G. Petry , Myléne Meynard , Michel Geffard
DOI: 10.1016/0165-5728(95)00061-6
关键词: Chemistry 、 Immune system 、 Epitope 、 Nitric oxide 、 Immunology 、 Amino acid 、 Molecular biology 、 Avidity 、 Antibody 、 Isotype 、 Multiple sclerosis
摘要: Abstract Converging data suggest that nitric oxide (NO) production by cytokine-induced immune cells in demyelinating lesions is involved multiple sclerosis (MS). High levels of NO may complex to suitable amino acids, causing an response against the formed neo-epitopes. By testing MS sera with chemically defined nitroso-amino acids conjugated carrier protein ELISA, we observed a significant antibody reaction S -nitroso-cysteine epitope. The was exclusively IgM isotype avidity 8 × 10 −7 M. Sera all clinical forms showed significantly elevated titer versus from healthy subjects or patients affected other neurological and autoimmune diseases. detection circulating antibodies epitope provides indirect evidence for involvement MS.
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