Urothelial bladder carcinoma and viral infections: different association with human polyomaviruses and papillomaviruses.

摘要: Bladder cancer is the second most commonly occurring genitourinary in adults. The interaction of different carcinogenic and cocarcinogenic agents are responsible for bladder urothelial carcinoma: alcohol smoking habits, Schistosoma haematobium infection, exposition to chemicals, analgesic antineoplastic drugs prolonged use. Recently also viral infections have been associated this pathology. In study correlation between carcinoma has evaluated. A group 32 patients affected by primary neoplasia analysed. control 20 autoptic samples healthy was DNA following viruses searched polymerase chain reaction (PCR): Adenovirus, Herpes simplex virus type 1 (HSV-1), 2 (HSV-2), Human Papillomaviruses (HPV), Polyomaviruses (BKV JCV). examined population association carcinoma-HPV, found others, not confirmed. high percentage human polyomaviruses present a statistically significant data (p=0.0087) allows presume that BKV JCV may play role aetiology tumor. particular polyomavirus BK, which significative both single infection (p=0.0036) co-infections with other species (p=0.035), be an important co-factor pathogenesis carcinoma.