Urinary human polyomavirus and papillomavirus infection and bladder cancer risk.

摘要: The association of transitional cell carcinomas the bladder (TCB) with Schistosoma haematobium suggested a possible role infections in aetiology TCB. In all, 114 TCB cases and 140 hospital controls from Pordenone Province were enrolled within an Italian multi-centric case–control study. Urine samples screened for DNA five human polyomaviruses (HPyV) (JCV, BKV, MCV, WUV, KIV); SV40; 22 mucosal papillomaviruses (HPV) using highly sensitive PCR assays. Odds ratios (ORs) corresponding confidence intervals (CIs) computed risk by HPyV- or HPV-positivity unconditional logistic regression. Human polyomavirus prevalence was similar (71.7%) (77.7%) (OR TCB=0.85; 95% CI: 0.45–1.61). JCV most frequently detected HPyV type. No individual showed significant association. Among cases, HPyV-positivity not associated tumour characteristics, but it significantly lower women than men among current former smokers never smokers. papillomavirus seven (OR=1.52; 0.42–5.45). present small study does support involvement HPV infection immunocompetent individuals. Differences sex smoking may derive differences either acquisition persistence infection.