siRNA delivery: from basics to therapeutic applications.

摘要: The chance to selectively intervene and stop the development of any gene-dependent disease in different organs pathologies makes siRNA an ideal therapeutic agent. However, serious issues should be addressed before real use siRNA. poor pharmacokinetic properties siRNA, its short half-life, low in vivo stability, fast elimination by kidney filtration low transfection efficiency complicate as a molecule. In this review, we will describe latest most advanced approaches strategies undertaken address these limitations improve delivery gene silencing efficacy well prospects for applications.