Novel nanosome delivery system combined with siRNA targeting the antimicrobial gene DFB4: a new approach for psoriasis management?

摘要: In a recently published issue of the journal, Bracke et al. demonstrate an impressive improvement in psoriasiform features allogeneic human skin grafts transplanted onto immune-deficient mice. This was achieved using novel nanosome (SECosome) as vehicle for delivering topically applied siRNA to epidermis. Targeting gene DFB4 with this delivery system, they prevented translation antimicrobial peptide, β defensin-2(hBD2), thus normalizing epidermal phenotype siRNA/SECosome-treated grafts. study encourages exploration topical silencing strategies dermatology and refocuses our attention on both, role hBD2 psoriasis pathogenesis thorny question which animal model reflects most faithfully.