Hippocampal CA3 and CA2 have distinct bilateral innervation patterns to CA1 in rodents

摘要: Ipsilateral and contralateral hippocampal CA3-CA1 CA2-CA1 projections were investigated in adult male Long-Evans rats by retrograde tracing. Injection of the tracer cholera toxin subunit B strata oriens radiatum dorsal CA1 resulted labeling predominantly pyramidal cells ipsilateral CA3 CA2. The anterior-posterior extents innervation to similar. Fifteen twenty per cent hippocampus proper that give rise stratum CA2 cells, whereas a mere 3% for innervation. preferred projection was also manifested transgenic mice express GFP under control CACNG5 promoter, which high amounts GFP. ratios compared. For connection, we found received more Interestingly, connections dominated both radiatum. These results demonstrate primary intrahippocampal target is oriens, contrast project diversely bilateral regions. Such patterns may suggest differential dendritic information processing apical basal dendrites cells.