Troglitazone stimulates IGF-binding protein-1 by a PPARγ-independent mechanism
作者： Agneta Hilding , Kerstin Hall , Josefin Skogsberg , Ewa Ehrenborg , Moira S Lewitt
DOI: 10.1016/S0006-291X(03)00403-0
关键词: Hepatocyte 、 Troglitazone 、 Thiazolidinedione 、 Rosiglitazone 、 Peroxisome proliferator-activated receptor 、 Paracrine signalling 、 Insulin 、 Endocrinology 、 Internal medicine 、 Glucose homeostasis 、 Chemistry
摘要: IGFBP-1 modulates IGF availability for glucose homeostasis and it may also play a paracrine role in hepatocyte survival. is inhibited transcriptionally by insulin regulated number of pathways that influence hepatic sensitivity. The effect the thiazolidinedione troglitazone on production was studied HepG2 human hepatoma cells, which were found to express PPAR alpha, gamma, PXR. Troglitazone stimulated mRNA expression 2-fold within 3h exposure (P<0.001) secretion up 3-fold over narrow dose range 24h (P<0.001). This mimicked PXR ligands clotrimazole phenobarbital, but not Wy14,643 or rosiglitazone, are alpha -gamma, respectively. We conclude cells independent involve
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