Stimulation of IGF-binding protein-1 secretion by AMP-activated protein kinase.
作者： Moira S. Lewitt
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摘要: Insulin-like growth factor-binding protein-1 (IGFBP-1) is stimulated during intensive exercise and in catabolic conditions to very high concentrations, which are not completely explained by known regulators such as insulin glucocorticoids. The role of AMP-activated protein kinase (AMPK), an important signaling system lipid carbohydrate metabolism, regulating IGFBP-1 was studied H4-II-E rat hepatoma cells. Arsenic(III) oxide 5-aminoimidazole-4-carboxamide-riboside (AICAR) were used activators. AICAR (150 microM) secretion twofold a 5-h incubation (P = 0.002). Insulin (100 ng/ml) inhibited 80% < 0.001), but this abolished the presence 150 microM AICAR. effect dexamethasone stimulating threefold additive 0.001) and, AICAR, incompletely insulin. In conclusion AMPK identified novel regulatory pathway for IGFBP-1, blocking inhibitory
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