Diabetic osteopathy and the IGF system in the Goto-Kakizaki rat.
作者： Tashfeen Ahmad , Anna Ugarph-Morawski , Moira S. Lewitt , Jian Li , Maria Sääf
DOI: 10.1016/J.GHIR.2008.02.003
关键词: Diaphysis 、 Diabetes mellitus 、 Long bone 、 Internal medicine 、 Osteoclast 、 Medicine 、 Bone mineral 、 Dual-energy X-ray absorptiometry 、 Cortical bone 、 Osteopenia 、 Endocrinology
摘要: Abstract Objective Diabetes mellitus is associated with an increased risk of osteopenia, fracture and Charcot arthropathy. Abnormalities the IGF system commonly observed in diabetes may underlie this “diabetic osteopathy” as IGF-I its binding proteins (IGFBPs) have been shown to affect osteoblast osteoclast activity. Design In type-2 diabetic control rats we analyzed IGFBP-1 -4 levels serum, notably, also cortical bone, ankles vertebrae by immunoassays. Osteopathy was assessed radiography dual energy X-ray absorptiometry. Results significantly reduced serum diaphyseal bone while IGFBP-4 were serum. The periosteal endosteal diameters diaphysis humerus tibia (changes similar those elderly humans) mineral density long metaphyses vertebrae. Conclusions Our study demonstrates both systemic local disturbances IGF-system diabetes, consistent enhanced erosion diaphyses, osteopenia Whether changes contribute osteopathy patients if treatment can reverse has yet be explored.
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