Serum levels of insulin-like growth factor (IGF)-I and IGF binding protein (IGFBP)-1 to -6 and their relationship to bone metabolism in osteoporosis patients.
作者： Peter M. Jehle , Klaus Schulten , Walter Schulz , Daniela R. Jehle , Sylvia Stracke
DOI: 10.1016/S0953-6205(02)00183-8
关键词:
摘要: BACKGROUND: Insulin-like growth factor (IGF) system components are important regulators of bone formation. Alterations individual IGF have been described in osteoporosis (OP) patients; however, no study has addressed changes free IGF-I and all six binding proteins (IGFBPs). METHODS: A cross-sectional was performed 45 OP patients 100 healthy matched controls. Serum levels total insulin-like I (IGF-I), IGFBP-1 through -6, intact parathyroid hormone (PTH), 25-OH-vitamin D(3) (25OHD(3)), 1,25-(OH)(2)-vitamin (1,25-(OH)(2)D(3)), osteocalcin (OSC), alkaline phosphatase (B-ALP), carboxyterminal propeptide type-I procollagen (PICP) were measured with specific assays. Bone mineral density (BMD) the lumbar spine determined by dual-energy X-ray absorptiometry (DEXA). RESULTS: Compared age- sex-matched control subjects, showed a 73% decrease IGF-I, 29% 10% IGFBP-3, 52% IGFBP-5 levels; they had higher (4.1-fold), IGFBP-2 (1.8-fold), IGFBP-4 (1.3-fold), IGFBP-6 (2.1-fold). most evident 13 vertebral fractures past 4 years compared to without fractures. In fractures, ratio between increased whereas OSC decreased. CONCLUSIONS: Our data provide strong indirect evidence for functional connection circulating metabolism susceptibility patients.
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sci-hub.se 参考文章(30)
Matthew M. Rechler, Insulin-like growth factor binding proteins. Vitamins and Hormones Series. ,vol. 47, pp. 1- 114 ,(1993) , 10.1016/S0083-6729(08)60444-6
Anna G. Johansson, David J. Baylink, Eva af Ekenstam, Erik Lindh, Subburaman Mohan, Sverker Ljunghall, Circulating levels of insulin-like growth factor-I and -II, and IGF-binding protein-3 in inflammation and after parathyroid hormone infusion Bone and Mineral. ,vol. 24, pp. 25- 31 ,(1994) , 10.1016/S0169-6009(08)80128-6
Tao Yan, Jon Wergedal, Yuehua Zhou, Subburaman Mohan, David J Baylink, Donna D Strong, Inhibition of human osteoblast marker gene expression by retinoids is mediated in part by insulin-like growth factor binding protein-6. Growth Hormone & Igf Research. ,vol. 11, pp. 368- 377 ,(2001) , 10.1054/GHIR.2001.0249
Alfredo J. Martínez, Mónica Pascual, Jesús Larralde, Acute effects of insulin-like growth factor-I (IGF-I) on bone protein synthesis in rats. Biochimica et Biophysica Acta. ,vol. 1199, pp. 101- 103 ,(1994) , 10.1016/0304-4165(94)90103-1
D. Nakaoka, T. Sugimoto, H. Kaji, M. Kanzawa, S. Yano, M. Yamauchi, T. Sugishita, K. Chihara, Determinants of bone mineral density and spinal fracture risk in postmenopausal Japanese women. Osteoporosis International. ,vol. 12, pp. 548- 554 ,(2001) , 10.1007/S001980170075
S Mohan, C Libanati, C Dony, K Lang, N Srinivasan, D J Baylink, Development, validation, and application of a radioimmunoassay for insulin-like growth factor binding protein-5 in human serum and other biological fluids. The Journal of Clinical Endocrinology and Metabolism. ,vol. 80, pp. 2638- 2645 ,(1995) , 10.1210/JCEM.80.9.7545694
S. Mohan, C. M. Bautista, J. Wergedal, D. J. Baylink, Isolation of an inhibitory insulin-like growth factor (IGF) binding protein from bone cell-conditioned medium: a potential local regulator of IGF action. Proceedings of the National Academy of Sciences. ,vol. 86, pp. 8338- 8342 ,(1989) , 10.1073/PNAS.86.21.8338
Subburaman Mohan, Yoshihide Nakao, Yoko Honda, Edwin Landale, Ulrike Leser, Carola Dony, Kurt Lang, David J. Baylink, Studies on the Mechanisms by Which Insulin-like Growth Factor (IGF) Binding Protein-4 (IGFBP-4) and IGFBP-5 Modulate IGF Actions in Bone Cells Journal of Biological Chemistry. ,vol. 270, pp. 20424- 20431 ,(1995) , 10.1074/JBC.270.35.20424
Peter M. Jehle, Antje Ostertag, Klaus Schulten, Walter Schulz, Daniela R. Jehle, Sylvia Stracke, Roman Fiedler, Heinz J. Deuber, Frieder Keller, Bernhard O. Boehm, David J. Baylink, Subburaman Mohan, Insulin-like growth factor system components in hyperparathyroidism and renal osteodystrophy Kidney International. ,vol. 57, pp. 423- 436 ,(2000) , 10.1046/J.1523-1755.2000.00862.X
K M Thrailkill, L D Quarles, H Nagase, K Suzuki, D M Serra, J L Fowlkes, Characterization of insulin-like growth factor-binding protein 5-degrading proteases produced throughout murine osteoblast differentiation. Endocrinology. ,vol. 136, pp. 3527- 3533 ,(1995) , 10.1210/ENDO.136.8.7543045