Acute effects of insulin-like growth factor-I (IGF-I) on bone protein synthesis in rats.
作者： Alfredo J. Martínez , Mónica Pascual , Jesús Larralde
DOI: 10.1016/0304-4165(94)90103-1
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摘要: Abstract The acute systematic effects of IGF-I on bone protein metabolism from hormonally intact rats have been investigated by measuring the fractional rate synthesis. animals received a single subcutaneous injection rhIGF-I (100 μg). Treatment with increased tibia synthesis (Ks) while plasma glucose and insulin concentrations were decreased. These results are in favor an endocrine role IGF stimulating growth.
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