Effects of mixtures of anticancer drugs in the benthic polychaete Nereis diversicolor.
作者： Tainá Garcia da Fonseca , Denis M.S. Abessa , Maria João Bebianno
DOI: 10.1016/J.ENVPOL.2019.05.095
关键词: Lipid peroxidation 、 Pharmacology 、 Neurotoxicity 、 Chemistry 、 Catalase 、 Genotoxicity 、 Superoxide dismutase 、 Antioxidant 、 Glutathione peroxidase 、 Toxicity
摘要: Abstract The increasing consumption of anticancer drugs through single and/or combinatory chemotherapy worldwide raised concern regarding their toxicity burden in coastal zones. a mixture three compounds involving the cisplatin (CisPt), cyclophosphamide (CP) and tamoxifen (TAM) was determined on marine polychaete Nereis diversicolor exposed to an range concentrations, respectively: Mix A: 0.1 + 10 + 0.1 ng L −1 ; B: 10 + 100 + 10 ng L C: 100 + 500 + 25 ng L D: 100 + 1000 + 100 ng L . Different endpoints were assessed, including disturbance burrowing behaviour, neurotoxicity (acetylcholinesterase – AChE activity), antioxidant enzymes (superoxide dismutase SOD; catalase CAT; selenium-dependent glutathione peroxidase Se-GPx total peroxidases T-GPx activities), biotransformation metabolism (glutathione-S-transferases - GST), lipid peroxidation (LPO) genotoxicity (DNA damage). Biological effects mixtures N. diversicolor compared with previous studies about same biological model under single-drug exposure conducted molecules. Regarding SOD activity, TAM showed antagonist effect over CisPt CP C D. In D, there synergistic that inhibited CAT activity additive interaction Phase II enzyme. Drugs A also suppressed polychaetes' GST although different from respective responses, besides able induce not sufficient avoid oxidative damage mid-grade DNA damage. Due absence impairment A, mechanisms involved other than one driven by alterations. At intermediary concentrations (Mix B C), only LPO occurred. Data individually may predict risks provided mixtures.
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