Ecotoxicological assessment of chemotherapeutic agents using toxicity tests with embryos of Mellita quinquiesperforata.

摘要: Abstract The consumption of anticancer agents has increased in the recent decades, and these substances may be present sewage. Consequently, they reach environment when sanitation infrastructure is ineffective. This study evaluated toxicity three agents—Tamoxifen (TAM), Cisplatin (CisPt), Cyclophosphamide (CP)—on development embryos sand-dollar Mellita quinquiesperforata. Adult individuals were collected sandy beaches, gametes obtained. Freshly-fertilized eggs exposed to increasing sets concentrations each compound, effective needed cause a 50% effect organisms (EC50) calculated. compounds toxic, their EC50 values 16.78 ± 2.42 ng·L−1 27.20 ± 38.26 ng·L−1 101.82 ± 70.96 ng·L−1 (CP). There no information on environmental levels Brazil, but as already detected ng·L−1 worldwide, it can expected that pose risks marine biota.