Agents and methods for treating ischemic and other diseases
作者： Michael Tymianski , Jonathan David Garman , Xiujun Sun
DOI:
关键词: Glaucoma 、 TRPM7 、 Cancer 、 Protein activity 、 Biology 、 Ischemia 、 Pharmacology
摘要: This invention relates to compounds that modulate TRPM7 protein activity and use of the same for treatment or prophylaxis ischemia, cancer, pain glaucoma.
lens.org 参考文章(24)
Elena S. Koltun, S. David Brown, Patrick Kearney, Pyridopyrimidinone inhibitors of PIM-1 and/or PIM-3 ,(2006)
Juha Kaivola, Marjo Yliperttula-Ikonen, Piero Pollesello, Carola Tilgmann, Martti Ovaska, Jukka Vidgren, Jukka Tenhunen, Timo Lotta, Compounds for deactivating phospholamban function on Ca-ATPase (phospholamban inhibitors) ,(1999)
Alexander L. Ruchelman, Hon-Wah Man, George W. Muller, Roger Shen-Chu Chen, 4′-O-substituted isoindoline derivatives and compositions comprising and methods of using the same ,(2008)
Noriyuki Furuichi, Hitoshi Iikura, Masayuki Matsushita, Toshihiro Aoki, Naoki Harada, Kenji Takanashi, Yasushi Tomii, Sawako Ozawa, Masahiro Sakaitani, Ikumi Hyoudoh, Pil-Su Ho, Fumio Watanabe, Novel coumarin derivative having antitumor activity ,(2007)
Henrik Sune Andersen, Gita Camilla Tejlgaard Kampen, Combination therapy using an 11beta-hydroxysteroid dehydrogenase type 1 inhibitor and a glucocorticoid receptor agonist to minimize the side effects associated with glucocorticoid receptor agonist therapy ,(2005)
Pascal Druzgala, Cyrus Becker, Materials and methods for treating coagulation disorders ,(2005)
Serge Kirkiacharian, Duong Thanh Thuy, Sames Sicsic, Robert Bakhchinian, Raffi Kurkjian, Thierry Tonnaire, Structure–activity relationships of some 3-substituted-4-hydroxycoumarins as HIV-1 protease inhibitors Farmaco. ,vol. 57, pp. 703- 708 ,(2002) , 10.1016/S0014-827X(02)01264-8
Andrea Behrenswerth, Nicole Volz, Jakob Toräng, Sonja Hinz, Stefan Bräse, Christa E. Müller, Synthesis and pharmacological evaluation of coumarin derivatives as cannabinoid receptor antagonists and inverse agonists Bioorganic & Medicinal Chemistry. ,vol. 17, pp. 2842- 2851 ,(2009) , 10.1016/J.BMC.2009.02.027
Karen A. Nolan, Jeremy R. Doncaster, Mark S. Dunstan, Katherine A. Scott, A. David Frenkel, David Siegel, David Ross, John Barnes, Colin Levy, David Leys, Roger C. Whitehead, Ian J. Stratford, Richard A. Bryce, Synthesis and Biological Evaluation of Coumarin-Based Inhibitors of NAD(P)H: Quinone Oxidoreductase-1 (NQO1) Journal of Medicinal Chemistry. ,vol. 52, pp. 7142- 7156 ,(2009) , 10.1021/JM9011609