ARNT-deficient mice and placental differentiation.
作者： Katherine R. Kozak , Barbara Abbott , Oliver Hankinson
关键词: Neural tube 、 Immunology 、 Forebrain 、 Knockout mouse 、 Biology 、 Yolk sac 、 Aryl hydrocarbon receptor nuclear translocator 、 Embryonic stem cell 、 Placenta 、 Embryo 、 Andrology
摘要: We used homologous recombination in embryonic stem cells to generate mice heterozygous for an aryl hydrocarbon nuclear translocator (ARNT) null mutation. These were intercrossed, but no live homozygousArnt−/− knockout produced among 64 newborns. Homozygotes diein uterobetween 9.5 and 10.5 days of gestation. Abnormalities included neural tube closure defects, forebrain hypoplasia, delayed rotation the embryo, placental hemorrhaging, visceral arch abnormalities. However, primary cause lethality appears be failure component placenta vascularize form labyrinthine spongiotrophoblast. This may related ARNT's known role hypoxic induction angiogenesis. found defects yolk sac circulation.
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