The biological basis of troponin in heart disease: possible uses for troponin fragmentology

作者: Allan S. Jaffe , Vlad C. Vasile

DOI:

关键词: Internal medicineClinical PracticeBiomarker (medicine)MedicineHeart diseaseCardiologyCardiac troponinBioinformaticsTroponin

摘要: This article describes the molecular biology of troponin in heart disease. Prospective uses for this biomarker are mentioned, with a particular emphasis on cardiac fragments that could be associated distinct clinical entities. The explores topic specific resulting from modification or degradation, linked different pathological processes, as indications novel potential In addition, it addresses some implications have an impact several circumstances confront physicians within practice. Heart Metab. 2009;43:5‐8.

参考文章(30)
Alexei Katrukha, Antibody Selection Strategies in Cardiac Troponin Assays Humana Press, Totowa, NJ. pp. 173- 185 ,(2003) , 10.1007/978-1-59259-385-9_10
S. V.PERRY, Troponin T: genetics, properties and function Journal of Muscle Research and Cell Motility. ,vol. 19, pp. 575- 602 ,(1998) , 10.1023/A:1005397501968
R Gahlmann, A B Troutt, R P Wade, P Gunning, L Kedes, Alternative splicing generates variants in important functional domains of human slow skeletal troponin T. Journal of Biological Chemistry. ,vol. 262, pp. 16122- 16126 ,(1987) , 10.1016/S0021-9258(18)47705-8
Benjamin J Freda, W.H.Wilson Tang, Frederick Van Lente, W.Franklin Peacock, Gary S Francis, Cardiac troponins in renal insufficiency: review and clinical implications. Journal of the American College of Cardiology. ,vol. 40, pp. 2065- 2071 ,(2002) , 10.1016/S0735-1097(02)02608-6
Roberto Bolli, Eduardo Marbán, Molecular and Cellular Mechanisms of Myocardial Stunning Physiological Reviews. ,vol. 79, pp. 609- 634 ,(1999) , 10.1152/PHYSREV.1999.79.2.609
Natalie Middleton, Keith George, Greg Whyte, David Gaze, Paul Collinson, Rob Shave, Cardiac troponin T release is stimulated by endurance exercise in healthy humans. Journal of the American College of Cardiology. ,vol. 52, pp. 1813- 1814 ,(2008) , 10.1016/J.JACC.2008.03.069
Soichi Takeda, Atsuko Yamashita, Kayo Maeda, Yuichiro Maéda, Structure of the core domain of human cardiac troponin in the Ca 2+ -saturated form Nature. ,vol. 424, pp. 35- 41 ,(2003) , 10.1038/NATURE01780
Hugo A. Katus, Andrew Remppis, Thomas Scheffold, Klaus W. Diederich, Wolfgang Kuebler, Intracellular compartmentation of cardiac troponin T and its release kinetics in patients with reperfused and nonreperfused myocardial infarction. American Journal of Cardiology. ,vol. 67, pp. 1360- 1367 ,(1991) , 10.1016/0002-9149(91)90466-X
Alma Mingels, Leo Jacobs, Etienne Michielsen, Joost Swaanenburg, Will Wodzig, Marja van Dieijen-Visser, Reference population and marathon runner sera assessed by highly sensitive cardiac troponin T and commercial cardiac troponin T and I assays. Clinical Chemistry. ,vol. 55, pp. 101- 108 ,(2009) , 10.1373/CLINCHEM.2008.106427
Stacy C. Smith, Jack H. Ladenson, Jay W. Mason, Allan S. Jaffe, Elevations of Cardiac Troponin I Associated With Myocarditis Experimental and Clinical Correlates Circulation. ,vol. 95, pp. 163- 168 ,(1997) , 10.1161/01.CIR.95.1.163