Integration of five groups of POPs into one multi-analyte method for human blood serum analysis: An innovative approach within biomonitoring studies
作者： Andrea Svarcova , Darina Lankova , Tomas Gramblicka , Michal Stupak , Jana Hajslova
DOI: 10.1016/J.SCITOTENV.2019.02.336
关键词: Quechers 、 Mass spectrometry 、 Liquid chromatography–mass spectrometry 、 Triple quadrupole mass spectrometer 、 Chromatography 、 Chemistry 、 Sample preparation 、 Gas chromatography–mass spectrometry 、 Tandem mass spectrometry 、 Gas chromatography
摘要: Abstract Within this study, a new analytical strategy was developed and validated for the simultaneous determination of 78 organohalogenated contaminants in human blood serum, namely 40 flame retardants (FRs) including 7 “novel” brominated chlorinated FRs (novel FRs), 19 perfluoroalkylated substances (PFASs), 11 organochlorine pesticides (OCPs) 8 polychlorinated biphenyls (PCBs). The integral sample preparation procedure implemented isolation non-polar compounds, based on three-step solvent extraction using mixture n-hexane:diethylether (9:1, v/v), followed by purification solid-phase (SPE) Florisil® column. For more polar lipophobic analytes, remaining fraction from first step further processed, modified QuEChERS method. Depending polarity volatility target either gas chromatography coupled to (tandem) mass spectrometry (GC–MS/(MS)), or ultra-high performance liquid triple quadrupole tandem (UHPLC-MS/MS), employed their identification/quantification. subsequent pilot successfully applied monitoring 38 samples serum obtained Prague, Czech Republic. From targeted 10 PFASs, OCPs, PCBs 6 BFRs were detected at concentrations above method quantification limits (MQLs). In samples, amounts determined PFASs range
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